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Article

Robustness of the linear mixed effects model to error distribution assumptions and the consequences for genome-wide association studies.

Statistical applications in genetics and molecular biology - 1 Oct 2014

Warrington Nicole M, Tilling Kate, Howe Laura D, Paternoster Lavinia, Pennell Craig E, Wu Yan Yan, Briollais Laurent

Abstract excerpt

Genome-wide association studies have been successful in uncovering novel genetic variants that are associated with disease status or cross-sectional phenotypic traits. Researchers are beginning to investigate how genes play a role in the development of a trait over time. Linear mixed effects models (LMM) are commonly used to model longitudinal data; however, it is unclear if the failure to meet the models...

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PMID: 25153607
DOI: 10.1515/sagmb-2013-0066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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