Article
Evaluation of prognostic integrin α2β1 PET tracer and concurrent targeting delivery using focused ultrasound for brain glioma detection.
Molecular pharmaceutics - 3 Nov 2014
Chung Yi-Hsiu, Hsu Po-Hung, Huang Chiun-Wei, Hsieh Wen-Chuan, Huang Feng-Ting, Chang Wen-Chi, Chiu Han, Hsu Shih-Ting, Yen Tzu-Chen
Abstract excerpt
The ability to early detect and assess the treatment response of recurrent and/or disseminated metastatic glioblastoma is critical for the effective management of this group of patients. Accumulating experimental evidence indicates that integrin α2β1 might be a prognostic biomarker for advanced phenotype of cancers. In this study, a novel (68)Ga-labeled integrin α2β1-targeted PET tracer (68)Ga-NOTA-PEG4-cyclo...
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