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Article

Early-onset Alzheimer's disease in two Iranian families: a genetic study.

Dementia and geriatric cognitive disorders - 1 Jan 2014

Noroozian Maryam, Azadfar Parisa, Akbari Leila, Sadeghi Arghavan, Houshmand Massoud, Vousooghi Nasim, Zarrindast Mohammad Reza, Minagar Alireza

Abstract excerpt

BACKGROUND: Early-onset Alzheimer's disease (EOAD) represents less than 5% of all AD cases. Autosomal dominant EOAD has been defined as the occurrence of at least three cases in three generations. Mutations in the amyloid precursor protein (APP), presenilin-1 and presenilin-2 genes have been recognized to be the cause of EOAD. OBJECTIVE: We investigated the genotype of EOAD in two generations of two families with...

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Identifiers

PMID: 25138979
DOI: 10.1159/000358232

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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