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Article

Mutations within a conserved region of vaccinia topoisomerase affect the DNA cleavage-religation equilibrium.

Journal of molecular biology - 25 Oct 1996

Petersen B O, Wittschieben J, Shuman S

Abstract excerpt

The segment of the vaccinia DNA topoisomerase from residues 143 to 167 (VGLLTLKNKHIEISPDEIVIKFVGK) is conserved in other members of the eukaryotic type I topoisomerase family. In order to gauge the function of this region, we performed a mutational analysis in which 23 of 25 positions were substi...

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Source

Identifiers

PMID: 8913300
DOI: 10.1006/jmbi.1996.0568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8913300-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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