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Article

A novel β-catenin signaling pathway activated by IL-1β leads to the onset of epithelial-mesenchymal transition in breast cancer cells.

Cancer letters - 1 Nov 2014

Perez-Yepez Eloy Andres, Ayala-Sumuano Jorge-Tonatiuh, Lezama Ruth, Meza Isaura

Abstract excerpt

Interleukin 1β has been associated with tumor development, invasiveness and metastasis in various types of cancer. However, the molecular mechanisms underlying this association have not been clearly elucidated. The present study is the first to show, in breast cancer cells, that an IL-1β/IL-1RI/β-catenin signaling pathway induces β-catenin accumulation due to GSK3β inactivation by Akt phosphorylation....

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Source

Identifiers

PMID: 25135221
DOI: 10.1016/j.canlet.2014.08.015

Genes

MMP2
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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