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Article

Transactivation of MCP‐1/CCL2 by β‐catenin/TCF‐4 in human breast cancer cells

7 Jul 2005

Abstract excerpt

The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of several genes, some of them having important implications in tumour progression. In our study, we...

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PMID: 16003740
DOI: 10.1002/ijc.21291

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