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Article

Fine-scale mapping of chromosome 9q22.33 identifies candidate causal variant in ovarian cancer.

PeerJ - 1 Jan 2024

Xing Tongyu, Zhao Yanrui, Wang Lili, Geng Wei, Liu Wei, Zhou Jingjing, Huang Caiyun, Wang Wei, Chu Xinlei, Liu Ben, Chen Kexin, Zheng Hong, Li Lian

Abstract excerpt

Ovarian cancer is a complex polygenic disease in which genetic factors play a significant role in disease etiology. A genome-wide association study (GWAS) identified a novel variant on chromosome 9q22.33 as a susceptibility locus for epithelial ovarian cancer (EOC) in the Han Chinese population. However, the underlying mechanism of this genomic region remained unknown. In this study, we conducted a fine-mapping...

Topics

Female
Humans
Genetic Predisposition to Disease
Genome-Wide Association Study
Ovarian Neoplasms
Quantitative Trait Loci
Carcinoma, Ovarian Epithelial
Chromosome Structures

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38371376
DOI: 10.7717/peerj.16918
PMCID: PMC10874173

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