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Article

SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.

Journal of hepatology - 1 Jan 2015

Zhang Zheng Yun, Hong Doopyo, Nam Seung Hoon, Kim Jong Man, Paik Yong Han, Joh Jae Won, Kwon Choon Hyuck David, Park Jae Berm, Choi Gyu-Seong, Jang Kyu Yun, Park Cheol Keun, Kim Sung Joo

Abstract excerpt

BACKGROUND & AIMS: SIRT1 is a class III histone deacetylase that plays diverse roles in various cancers. However, the clinical significance of SIRT1 in hepatocellular carcinoma (HCC) remains unknown. METHODS: We analysed p53 mutations and the activation of SIRT1 in 252 hepatitis B virus-positive HCC cases. None of the patients had been subjected to pre-operative treatment. RESULTS: We examined 57 p53 mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25131770
DOI: 10.1016/j.jhep.2014.08.007

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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