Withdrawal of skeletal muscle cells from cell cycle progression triggers differentiation ofToxoplasma gondiitowards the bradyzoite stage

Abstract excerpt

Toxoplasma gondii is a widespread intracellular parasite of mammals and birds and an important opportunistic pathogen of humans. Following primary infection, fast-replicating tachyzoites disseminate within the host and either are subsequently eliminated by the immune system or transform to latent bradyzoites which preferentially persist in brain and muscle tissues. The factors which determine the parasites'...

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