Article
ABCB1 Is Upregulated in Acquisition of Taxane Resistance: Lessons from Esophageal Squamous Cell Carcinoma Cell Lines.
The Tohoku journal of experimental medicine - 1 Dec 2016
Wang Ruobing, Sumarpo Anton, Saiki Yuriko, Chen Na, Sunamura Makoto, Horii Akira
Abstract excerpt
Esophageal cancer is one of the common malignancies worldwide, particularly in eastern African and Asian countries including Japan. Taxane (paclitaxel or docetaxel) is one of the effective chemotherapeutic reagents for patients with esophageal cancer, but acquisition of chemoresistance frequently occurs; this is one of the most frequent causes for therapeutic failure. In this study, we established three taxane...
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