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Article

Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression.

PloS one - 1 Jan 2012

Zhu Hongwu, Xia Limin, Zhang Yongguo, Wang Honghong, Xu Wenjing, Hu Hao, Wang Jing, Xin Jing, Gang Yi, Sha Sumei, Xu Bin, Fan Daiming, Nie Yongzhan, Wu Kaichun

Abstract excerpt

BACKGROUND: Multidrug resistance (MDR) in gastric cancer remains a major challenge to clinical treatment. Activating transcription factor 4 (ATF4) is a stress response gene involved in homeostasis and cellular protection. However, the expression and function of ATF4 in gastric cancer MDR remains...

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Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to bcl-2-Associated X Protein

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Share to RNA, Small Interfering

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Source

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Identifiers

PMID: 22363646
DOI: 10.1371/journal.pone.0031431
PMCID: PMC3281959

Genes

ATF4
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22363646-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression.PMID 22363646Read ↗

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