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Article

Competence in Streptococcus pneumoniae is a response to an increasing mutational burden.

PloS one - 1 Jan 2013

Gagne Alyssa L, Stevens Kathleen E, Cassone Marco, Pujari Amit, Abiola Olufunke E, Chang Diana J, Sebert Michael E

Abstract excerpt

Competence for genetic transformation in Streptococcus pneumoniae has previously been described as a quorum-sensing trait regulated by a secreted peptide pheromone. Recently we demonstrated that competence is also activated by reduction in the accuracy of protein biosynthesis. We have now investigated whether errors upstream of translation in the form of random genomic mutations can provide a similar stimulus....

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Share to DNA Mismatch Repair
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Fitness

Share to Mutagenesis

Share to Quantitative Trait, Heritable

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Source

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Identifiers

PMID: 23967325
DOI: 10.1371/journal.pone.0072613
PMCID: PMC3742669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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