Article
Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.
JAMA neurology - 1 Oct 2014
Mak Angel C Y, Pullinger Clive R, Tang Ling Fung, Wong Jinny S, Deo Rahul C, Schwarz Jean-Marc, Gugliucci Alejandro, Movsesyan Irina, Ishida Brian Y, Chu Catherine, Poon Annie, Kim Phillip, Stock Eveline O, Schaefer Ernst J, Asztalos Bela F, Castellano Joseph M, Wyss-Coray Tony, Duncan Jacque L, Miller Bruce L, Kane John P, Kwok Pui-Yan, Malloy Mary J
Abstract excerpt
IMPORTANCE: The identification of a patient with a rare form of severe dysbetalipoproteinemia allowed the study of the consequences of total absence of apolipoprotein E (apoE). OBJECTIVES: To discover the molecular basis of this rare disorder and to determine the effects of complete absence of apoE on neurocognitive and visual function and on lipoprotein metabolism. DESIGN, SETTING, AND PARTICIPANTS: Whole-exome...
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