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Article

Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.

JAMA neurology - 1 Oct 2014

Mak Angel C Y, Pullinger Clive R, Tang Ling Fung, Wong Jinny S, Deo Rahul C, Schwarz Jean-Marc, Gugliucci Alejandro, Movsesyan Irina, Ishida Brian Y, Chu Catherine, Poon Annie, Kim Phillip, Stock Eveline O, Schaefer Ernst J, Asztalos Bela F, Castellano Joseph M, Wyss-Coray Tony, Duncan Jacque L, Miller Bruce L, Kane John P, Kwok Pui-Yan, Malloy Mary J

Abstract excerpt

IMPORTANCE: The identification of a patient with a rare form of severe dysbetalipoproteinemia allowed the study of the consequences of total absence of apolipoprotein E (apoE). OBJECTIVES: To discover the molecular basis of this rare disorder and to determine the effects of complete absence of ap...

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Source

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Identifiers

PMID: 25111166
DOI: 10.1001/jamaneurol.2014.2011
PMCID: PMC4714860

Genes

ABCC2
APOE
LIPC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25111166-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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