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Article

Mitochondrial dysfunction in cancer chemoresistance.

Biochemical pharmacology - 1 Nov 2014

Guaragnella Nicoletta, Giannattasio Sergio, Moro Loredana

Abstract excerpt

Mitochondrial dysfunction has been associated with cancer development and progression. Recent evidences suggest that pathogenic mutations or depletion of the mitochondrial genome can contribute to development of chemoresistance in malignant tumors. In this review we will describe the current knowledge on the role of mitochondrial dysfunction in the development of chemoresistance in cancer. We will also discuss...

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PMID: 25107705
DOI: 10.1016/j.bcp.2014.07.027

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