Article
Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms.
Science China. Life sciences - 1 Sept 2014
Yuan DeJian, Zhu ZuoBin, Tan XiaoHua, Liang Jie, Zeng Chen, Zhang JieGen, Chen Jun, Ma Long, Dogan Ayca, Brockmann Gudrun, Goldmann Oliver, Medina Eva, Rice Amanda D, Moyer Richard W, Man Xian, Yi Ke, Li YanKe, Lu Qing, Huang YiMin, Huang Shi
Abstract excerpt
It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness. However, the collective effects of SNPs have yet to be examined by experimental science. We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations. We identified the minor alleles...
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