Frequency of AIP gene mutations in young patients with acromegaly: a registry-based study.

doi:10.1210/jc.2014-2094

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Article

Frequency of AIP gene mutations in young patients with acromegaly: a registry-based study.

The Journal of clinical endocrinology and metabolism - 1 Dec 2014

Schöfl Christof, Honegger Jürgen, Droste Michael, Grussendorf Martin, Finke Reinhard, Plöckinger Ursula, Berg Christian, Willenberg Holger S, Lammert Alexander, Klingmüller Dietrich, Jaursch-Hancke Cornelia, Tönjes Anke, Schneidewind Sabine, Flitsch Jörg, Bullmann Catharina, Dimopoulou Christina, Stalla Günter, Mayr Bernhard, Hoeppner Wolfgang, Schopohl Jochen

Abstract excerpt

CONTEXT: Familial and sporadic GH-secreting pituitary adenomas are associated with mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene. Patients with an AIP mutation (AIPmut) tend to have more aggressive tumors occurring at a younger age. OBJECTIVE: The objective of the study was to investigate the frequency of AIPmut in patients diagnosed at 30 years of age or younger. DESIGN: The German...

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PMID: 25093619
DOI: 10.1210/jc.2014-2094

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