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Article

Germline AIP mutations in apparently sporadic pituitary adenomas: prevalence in a prospective single-center cohort of 443 patients.

The Journal of clinical endocrinology and metabolism - 1 Apr 2012

Cazabat Laure, Bouligand Jérôme, Salenave Sylvie, Bernier Michèle, Gaillard Stephan, Parker Fabrice, Young Jacques, Guiochon-Mantel Anne, Chanson Philippe

Abstract excerpt

CONTEXT: Germline mutations of the AIP (aryl-hydrocarbon receptor interacting protein) gene are associated with a predisposition to pituitary adenomas. Such mutations are found in about half of patients with familial acromegaly, but penetrance is incomplete. OBJECTIVE: We studied the prevalence of germline AIP mutations in a large cohort of patients with apparently sporadic pituitary adenomas. PATIENTS AND...

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Source

Identifiers

PMID: 22319033
DOI: 10.1210/jc.2011-2291

Genes

AIP
MEN1
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Germline AIP mutations in apparently sporadic pituitary adenomas: prevalence in a prospective single-center cohort of 443 patients.PMID 22319033Read ↗

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Low frequency of AIP mutations in patients with young-onset sporadic pituitary macroadenomas.Semantic proximity Read ↗

Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas.Semantic proximity Read ↗

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