High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas.

doi:10.1530/EJE-11-0304

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Article

High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas.

European journal of endocrinology - 1 Oct 2011

Tichomirowa Maria A, Barlier Anne, Daly Adrian F, Jaffrain-Rea Marie-Lise, Ronchi Cristina, Yaneva Maria, Urban Jonathan D, Petrossians Patrick, Elenkova Atanaska, Tabarin Antoine, Desailloud Rachel, Maiter Dominique, Schürmeyer Thomas, Cozzi Renato, Theodoropoulou Marily, Sievers Caroline, Bernabeu Ignacio, Naves Luciana A, Chabre Olivier, Montañana Carmen Fajardo, Hana Vaclav, Halaby Georges, Delemer Brigitte, Aizpún José Ignacio Labarta, Sonnet Emmanuel, Longás Angel Ferrandez, Hagelstein Marie-Thérèse, Caron Philippe, Stalla Günter K, Bours Vincent, Zacharieva Sabina, Spada Anna, Brue Thierry, Beckers Albert

Abstract excerpt

BACKGROUND: Aryl hydrocarbon receptor interacting protein (AIP) mutations (AIPmut) cause aggressive pituitary adenomas in young patients, usually in the setting of familial isolated pituitary adenomas. The prevalence of AIPmut among sporadic pituitary adenoma patients appears to be low; studies have not addressed prevalence in the most clinically relevant population. Hence, we undertook an international,...

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PMID: 21753072
DOI: 10.1530/EJE-11-0304

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