Article
Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression.
Advances in cancer research - 1 Jan 2014
Adamia Sophia, Kriangkum Jitra, Belch Andrew R, Pilarski Linda M
Abstract excerpt
It is becoming increasingly apparent that splicing defects play a key role in cancer, and that alterations in genomic splicing elements promote aberrant splicing. Alternative splicing increases the diversity of the human transcriptome and increases the numbers of functional gene products. However, dysregulation that leads to aberrant pre-mRNA splicing can contribute to cancer. Hyaluronan (HA), known to be an...
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