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Article

Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer.

PloS one - 1 Jan 2014

Kuppusamy Hemalatha, Ogmundsdottir Helga M, Baigorri Eva, Warkentin Amanda, Steingrimsdottir Hlif, Haraldsdottir Vilhelmina, Mant Michael J, Mackey John, Johnston James B, Adamia Sophia, Belch Andrew R, Pilarski Linda M

Abstract excerpt

Genetic variations in the hyaluronan synthase 1 gene (HAS1) influence HAS1 aberrant splicing. HAS1 is aberrantly spliced in malignant cells from multiple myeloma (MM) and Waldenstrom macroglobulinemia (WM), but not in their counterparts from healthy donors. The presence of aberrant HAS1 splice variants predicts for poor survival in multiple myeloma (MM). We evaluated the influence of inherited HAS1 single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24950197
DOI: 10.1371/journal.pone.0100691
PMCID: PMC4065063

Genes

HAS1

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Related research

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Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer.PMID 24950197Read ↗

Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia.Semantic proximity Read ↗

Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myelomaSemantic proximity Read ↗

Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert Pre-mRNA [corrected] splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes.Semantic proximity Read ↗

Genetic abnormalities in Waldenström's macroglobulinemia.Semantic proximity Read ↗

Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia.Semantic proximity Read ↗

Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression.Semantic proximity Read ↗

Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance.Semantic proximity Read ↗

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Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalitiesSemantic proximity Read ↗

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