Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of germline transmission from chimeras by IVF after sperm analysis.

Transgenic research - 1 Feb 2015

Li Ming-Wen, Willis Brandon J, Evans Kristin D, Araiza Renee S, Lee Angus Yiu-Fai, Lloyd K C Kent

Abstract excerpt

Successful production of genetically modified mouse lines is dependent on germline transmission (GLT) of mutant alleles from chimeras. When natural mating fails to achieve GLT due to male infertility, sickness, or other problems, sperm can be harvested from chimeras and used for assisted reproductive technologies such as in vitro fertilization (IVF) to attempt to "rescue" GLT. However, a rational, evidence-based...

Topics

Animals
Animals, Genetically Modified
Chimera
Embryo, Mammalian
Embryonic Stem Cells
Fertilization in Vitro
Genotype
Germ Cells
Male
Mice
Spermatogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 25080098
DOI: 10.1007/s11248-014-9819-7
PMCID: PMC4276497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of germline transmission from chimeras by IVF after sperm analysis.PMID 25080098Read ↗

Combining sperm plug genotyping and coat color chimerism predicts germline transmission.Semantic proximity Read ↗

The Power of Mouse Genetics to Study SpermatogenesisSemantic proximity Read ↗

Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'.Semantic proximity Read ↗

Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.Semantic proximity Read ↗

Exclusive transmission of the embryonic stem cell-derived genome through the mouse germline.Semantic proximity Read ↗

Transplantation of germ line stem cells for the study and manipulation of spermatogenesis.Semantic proximity Read ↗

Germ cell transplantation into mouse testes procedure.Semantic proximity Read ↗

Restoration of Fertility by Germ Cell Transplantation Requires Effective Recipient Preparation1Semantic proximity Read ↗

Intracytoplasmic sperm injection induces transgenerational abnormalities in miceSemantic proximity Read ↗

Identification of germline competent chimaeras by copulatory plug genotyping.Semantic proximity Read ↗

Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoidsSemantic proximity Read ↗

Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.