Article
H3K27me3 profiling of the endosperm implies exclusion of polycomb group protein targeting by DNA methylation.
PLoS genetics - 7 Oct 2010
Weinhofer Isabelle, Hehenberger Elisabeth, Roszak Pawel, Hennig Lars, Köhler Claudia
Abstract excerpt
Polycomb group (PcG) proteins act as evolutionary conserved epigenetic mediators of cell identity because they repress transcriptional programs that are not required at particular developmental stages. Each tissue is likely to have a specific epigenetic profile, which acts as a blueprint for its developmental fate. A hallmark for Polycomb Repressive Complex 2 (PRC2) activity is trimethylated lysine 27 on histone...
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