Article
Presence of the full-length KIR2DS4 gene reduces the chance of rheumatoid arthritis patients to respond to methotrexate treatment.
BMC musculoskeletal disorders - 28 Jul 2014
Majorczyk Edyta, Pawlik Andrzej, Gendosz Daria, Kuśnierczyk Piotr
Abstract excerpt
BACKGROUND: KIR genes coding for natural killer cell immunoglobulin-like receptors, KIR, influence the effector and regulatory function of NK cells as well as some subpopulations of T lymphocytes (e.g. CD4+CD28-KIR+) depending on presence of ligands (particularly HLA-C molecules). KIR-KIR ligand interaction may lead to the development of autoimmune disorders, including rheumatoid arthritis (RA). However, their...
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