Article
Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis.
The Journal of experimental medicine - 21 May 2001
Yen J H, Moore B E, Nakajima T, Scholl D, Schaid D J, Weyand C M, Goronzy J J
Abstract excerpt
Rheumatoid arthritis (RA) is a heterogeneous syndrome of which a subset of patients develops vascular inflammation. The genetic determinants that confer risk for rheumatoid vasculitis are not known, but patients with vascular complications are known to have an expansion of CD4(+)CD28(null) T cells, a cell population potentially involved in endothelial damage. CD4(+)CD28(null) T cell clones isolated from RA...
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