Article
Analysis of chromosomal structural variation in patients with congenital left-sided cardiac lesions.
Birth defects research. Part A, Clinical and molecular teratology - 1 Dec 2014
White Peter S, Xie Hongbo M, Werner Petra, Glessner Joseph, Latney Brande, Hakonarson Hakon, Goldmuntz Elizabeth
Abstract excerpt
BACKGROUND: We sought to characterize the landscape of structural variation associated with the subset of congenital cardiac defects characterized by left-sided obstruction. METHODS: Cases with left-sided cardiac defects (LSCD) and pediatric controls were uniformly genotyped and assessed for copy number variant (CNV) calls. Significance testing was performed to ascertain differences in overall CNV incidence, and...
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