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Article

Rare Copy Number Variants Contribute to Congenital Left-Sided Heart Disease

6 Sept 2012

Abstract excerpt

Left-sided congenital heart disease (CHD) encompasses a spectrum of malformations that range from bicuspid aortic valve to hypoplastic left heart syndrome. It contributes significantly to infant mortality and has serious implications in adult cardiology. Although left-sided CHD is known to be highly heritable, the underlying genetic determinants are largely unidentified. In this study, we sought to determine the...

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PMID: 22969434
DOI: 10.1371/journal.pgen.1002903

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