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Article

Growth differentiation factor-15 in young sickle cell disease patients: relation to hemolysis, iron overload and vascular complications.

Blood cells, molecules & diseases - 1 Dec 2014

Tantawy Azza Abdel Gawad, Adly Amira Abdel Moneam, Ismail Eman Abdel Rahman, Darwish Yasser Wagih, Ali Zedan Marwa

Abstract excerpt

BACKGROUND: High expression of growth differentiation factor-15 (GDF-15) contributes to pathological iron overload in thalassemia. Sickle cell syndromes are characterized by increased levels of erythropoiesis, although the primary defect involves the destruction of mature erythrocytes. AIM: To determine serum GDF-15 in 35 children and adolescents with sickle cell disease (SCD) compared to 35 healthy controls and...

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Identifiers

PMID: 25065856
DOI: 10.1016/j.bcmd.2014.07.003

Genes

SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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