Short self-interacting N-terminal region of rubella virus capsid protein is essential for cooperative actions of capsid and nonstructural p150 proteins.

Abstract excerpt

UNLABELLED: Nucleocapsid formation is a primary function of the rubella virus capsid protein, which also promotes viral RNA synthesis via an unknown mechanism. The present study demonstrates that in infected cells, the capsid protein is associated with the nonstructural p150 protein via the short self-interacting N-terminal region of the capsid protein. Mutational analyses indicated that hydrophobic amino acids...

Topics

• Amino Acid Sequence
• Animals
• Capsid
• Capsid Proteins
• Chlorocebus aethiops
• Gene Expression Regulation, Viral
• HEK293 Cells
• Humans
• Hydrophobic and Hydrophilic Interactions
• Molecular Sequence Data
• Mutation
• Protein Binding
• Protein Interaction Domains and Motifs