Article
Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma.
Oncotarget - 15 Aug 2014
Su Wen-Pin, Hsu Sen-Huei, Wu Cheng-Kuei, Chang Song-Bin, Lin Yi-Ju, Yang Wen-Bin, Hung Jan-Jong, Chiu Wen-Tai, Tzeng Shun-Fen, Tseng Yau-Lin, Chang Jang-Yang, Su Wu-Chou, Liaw Hungjiun
Abstract excerpt
Cisplatin can cause intrastrand and interstrand crosslinks between purine bases and is a chemotherapeutic drug widely used to treat cancer. However, the major barrier to the efficacy of the treatment is drug resistance. Homologous recombination (HR) plays a central role in restoring stalled forks caused by DNA lesions. Here, we report that chronic treatment with cisplatin induces HR to confer cisplatin resistance...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.