Identification of genes associated with cisplatin resistance in human oral squamous cell carcinoma cell line.

doi:10.1186/1471-2407-6-224

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Article

Identification of genes associated with cisplatin resistance in human oral squamous cell carcinoma cell line.

BMC cancer - 15 Sept 2006

Zhang Ping, Zhang Zhiyuan, Zhou Xiaojian, Qiu Weiliu, Chen Fangan, Chen Wantao

Abstract excerpt

BACKGROUND: Cisplatin is widely used for chemotherapy of head and neck squamous cell carcinoma. However, details of the molecular mechanism responsible for cisplatin resistance are still unclear. The aim of this study was to identify the expression of genes related to cisplatin resistance in oral squamous cell carcinoma cells. METHODS: A cisplatin-resistant cell line, Tca/cisplatin, was established from a...

Topics

Carcinoma, Squamous Cell
Cell Cycle
Cell Line, Tumor
Cisplatin
Cyclin D1
Cyclin D3
Cyclins
Drug Resistance, Neoplasm
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Mouth Neoplasms
Phenotype
Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 16978399
DOI: 10.1186/1471-2407-6-224
PMCID: PMC1586025

Genes

CCND1
CCND3
RECQL

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