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Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA

8 Jul 2014

Abstract excerpt

The heart has a limited capacity for regeneration following injury. Recent strategies to promote heart regeneration have largely focused on autologous and allogeneic cell-based therapy, where the transplanted cells have been suggested to secrete unknown paracrine factors that are envisioned to promote endogenous repair and/or mobilization of endogenous heart progenitors. Here, we discuss the importance of...

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PMID: 25043723
DOI: 10.1016/j.scr.2014.06.007

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