Article
ECM hydrogel coating mitigates the chronic inflammatory response to polypropylene mesh.
Biomaterials - 1 Oct 2014
Faulk Denver M, Londono Ricardo, Wolf Matthew T, Ranallo Christian A, Carruthers Christopher A, Wildemann Justin D, Dearth Christopher L, Badylak Stephen F
Abstract excerpt
Polypropylene has been used as a surgical mesh material for several decades. This non-degradable synthetic polymer provides mechanical strength, a predictable host response, and its use has resulted in reduced recurrence rates for ventral hernia and pelvic organ prolapse. However, polypropylene and similar synthetic materials are associated with a chronic local tissue inflammatory response and dense fibrous...
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