Article
De novo acute myeloid leukemia with 20-29% blasts is less aggressive than acute myeloid leukemia with ≥30% blasts in older adults: a Bone Marrow Pathology Group study.
American journal of hematology - 1 Nov 2014
Hasserjian Robert Paul, Campigotto Federico, Klepeis Veronica, Fu Bin, Wang Sa A, Bueso-Ramos Carlos, Cascio Michael Joseph, Rogers Heesun Joyce, Hsi Eric Darryl, Soderquist Craig, Bagg Adam, Yan Jiong, Ochs Rachel, Orazi Attilio, Moore Frank, Mahmoud Amer, George Tracy Irene, Foucar Kathryn, Odem Jamie, Booth Cassie, Morice William, DeAngelo Daniel J, Steensma David, Stone Richard Maury, Neuberg Donna, Arber Daniel Alan
Abstract excerpt
It is controversial whether acute myeloid leukemia (AML) patients with 20-29% bone marrow (BM) blasts, formerly referred to as refractory anemia with excess blasts in transformation (RAEBT), should be considered AML or myelodysplastic syndrome (MDS) for the purposes of treatment and prognostication. We retrospectively studied 571 de novo AML in patients aged >50 years, including 142 RAEBT and 429 with ≥30% blasts...
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