Article
Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death.
FEBS letters - 25 Aug 2014
Nomikos Michail, Thanassoulas Angelos, Beck Konrad, Vassilakopoulou Vyronia, Hu Handan, Calver Brian L, Theodoridou Maria, Kashir Junaid, Blayney Lynda, Livaniou Evangelia, Rizkallah Pierre, Nounesis George, Lai F Anthony
Abstract excerpt
Calmodulin (CaM) association with the cardiac muscle ryanodine receptor (RyR2) regulates excitation-contraction coupling. Defective CaM-RyR2 interaction is associated with heart failure. A novel CaM mutation (CaM(F90L)) was recently identified in a family with idiopathic ventricular fibrillation (IVF) and early onset sudden cardiac death. We report the first biochemical characterization of CaM(F90L). F90L confers...
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