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Article

Convergent evolution of IL-6 in two leporids (Oryctolagus and Pentalagus) originated an extended protein.

Immunogenetics - 1 Oct 2014

Neves Fabiana, Abrantes Joana, Pinheiro Ana, Almeida Tereza, Costa Paulo P, Esteves Pedro J

Abstract excerpt

Interleukin 6 (IL-6) is a class-I helical cytokine with a broad spectrum of biological activities and a gene structure conserved throughout vertebrates, with five coding exons. IL-6 from European rabbits belonging to the subspecies Oryctolagus cuniculus cuniculus was previously shown to differ from other mammals by extending an additional 27 amino acids. However, in other leporids (Sylvilagus spp and Lepus spp)...

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PMID: 25027474
DOI: 10.1007/s00251-014-0787-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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