Article
Copy number polymorphism of glutathione-S-transferase genes (GSTM1 & GSTT1) in susceptibility to lung cancer in a high-risk population from north-east India.
The Indian journal of medical research - 1 May 2014
Ihsan Rakhshan, Chauhan Pradeep Singh, Mishra Ashwani Kumar, Singh L C, Sharma Jagannath Dev, Zomawia Eric, Verma Yogesh, Kapur Sujala, Saxena Sunita
Abstract excerpt
BACKGROUND & OBJECTIVES: Genetic polymorphisms in glutathione-S-transferase genes ( GSTM1 and GSTT1 ) have been studied intensively for their potential role in lung cancer susceptibility. However, most of the studies on association between the polymorphisms and lung cancer do not distinguish between genotypes with one or two copies of the genes. The present study investigates the gene dosage effects of GSTT1 and...
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