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Article

BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2014

Xing Mingzhao, Liu Rengyun, Liu Xiaoli, Murugan Avaniyapuram Kannan, Zhu Guangwu, Zeiger Martha A, Pai Sara, Bishop Justin

Abstract excerpt

PURPOSE: To investigate the prognostic value of the BRAF V600E mutation and the recently identified TERT promoter mutation chr5:1,295,228C>T (C228T), individually and in their coexistence, in papillary thyroid cancer (PTC). PATIENTS AND METHODS: We performed a retrospective study of the relationship of BRAF and TERT C228T mutations with clinicopathologic outcomes of PTC in 507 patients (365 women and 142 men) age...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25024077
DOI: 10.1200/JCO.2014.55.5094
PMCID: PMC4145183

Genes

BRAF
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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