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Article

Genetic trio of BRAF and TERT alterations and rs2853669TT in papillary thyroid cancer aggressiveness.

Journal of the National Cancer Institute - 8 May 2024

Liu Rengyun, Zhu Guangwu, Tan Jie, Shen Xiaopei, Xing Mingzhao

Abstract excerpt

BACKGROUND: BRAF V600E and TERT promoter alterations are core components in current genetics-based risk assessment for precision management of papillary thyroid cancer. It remains unknown whether this approach could achieve even better precision through a widely recognized prognostic single-nucleotide variation (SNV, formerly SNP), rs2853669T>C, in the TERT promoter. METHODS: The genetic status of alterations and...

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Topics

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Share to Carcinoma, Papillary
Share to Neoplasm Recurrence, Local

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prognosis

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins B-raf

Share to Telomerase

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 38113409
DOI: 10.1093/jnci/djad265
PMCID: PMC11077312

Genes

TERT
BRAF

Variants

Provenance

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