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Article

β-catenin (CTNNB1) mutations are not associated with prognosis in advanced hepatocellular carcinoma.

Oncology - 1 Jan 2014

Lu Li-Chun, Shao Yu-Yun, Lee Yi-Hsuan, Hsieh Min-Shu, Hsiao Chi-Huang, Lin Hsiao-Hui, Kao Hsiang-Fong, Ma Yu-Yi, Yen Feng-Chu, Cheng Ann-Lii, Hsu Chih-Hung

Abstract excerpt

OBJECTIVES: Mutation of the exon 3 of CTNNB1, the coding gene of β-catenin, is a crucial molecular mechanism leading to aberrant activation of the Wnt/β-catenin pathway, which is highly associated with the carcinogenesis of hepatocellular carcinoma (HCC). The prevalence and clinical significance of CTNNB1 mutations in advanced HCC remain unclear. METHODS: Patients with advanced HCC and available pathologic...

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Identifiers

PMID: 25012536
DOI: 10.1159/000362821

Genes

CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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