Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a major phosphopeptide in human tristetraprolin by phosphopeptide mapping and mass spectrometry.

PloS one - 1 Jan 2014

Cao Heping, Deterding Leesa J, Blackshear Perry J

Abstract excerpt

Tristetraprolin/zinc finger protein 36 (TTP/ZFP36) binds and destabilizes some pro-inflammatory cytokine mRNAs. TTP-deficient mice develop a profound inflammatory syndrome due to excessive production of pro-inflammatory cytokines. TTP expression is induced by various factors including insulin and extracts from cinnamon and green tea. TTP is highly phosphorylated in vivo and is a substrate for several protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to HEK293 Cells
Share to Peptide Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phosphopeptides

Share to Proteolysis

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Trypsin

Source

Open in PubMed Open full text

Identifiers

PMID: 25010646
DOI: 10.1371/journal.pone.0100977
PMCID: PMC4091943

Genes

ZFP36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a major phosphopeptide in human tristetraprolin by phosphopeptide mapping and mass spectrometry.PMID 25010646Read ↗

Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis.Semantic proximity Read ↗

Quantitative evaluation of His-tag purification and immunoprecipitation of tristetraprolin and its mutant proteins from transfected human cells.Semantic proximity Read ↗

Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3' untranslated region.Semantic proximity Read ↗

Tristetraprolin expression by keratinocytes controls local and systemic inflammationSemantic proximity Read ↗

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expressionSemantic proximity Read ↗

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.Semantic proximity Read ↗

Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in MiceSemantic proximity Read ↗

Tristetraprolin Is Required for Alveolar Bone Homeostasis.Semantic proximity Read ↗

A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency.Semantic proximity Read ↗

Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stabilitySemantic proximity Read ↗

Novel phosphorylation-dependent ubiquitination of tristetraprolin by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1) and tumor necrosis factor receptor-associated factor 2 (TRAF2).Semantic proximity Read ↗

The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.