Article
β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2011
Ballana Ester, Pauls Eduardo, Clotet Bonaventura, Perron-Sierra Françoise, Tucker Gordon C, Esté José A
Abstract excerpt
Monocytes and macrophages are targets of HIV-1 infection and play critical roles in multiple aspects of viral pathogenesis. During the differentiation of monocytes to macrophages, adhesion molecules such as integrins are upregulated; therefore, they provide signals that control the process and subsequently may render macrophages more susceptible to HIV-1 infection. Previous work demonstrated that blocking...
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