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Article

Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis.

American journal of physiology. Renal physiology - 1 Sept 2014

McMillan Matthew T, Pan Xiao-Qing, Smith Ariana L, Newman Diane K, Weiss Susan R, Ruggieri Michael R, Malykhina Anna P

Abstract excerpt

In the present study, we aimed to determine whether mice with coronavirus-induced encephalomyelitis (CIE) develop neurogenic bladder dysfunction that is comparable with the neurogenic detrusor overactivity observed in patients with multiple sclerosis. Adult mice (C57BL/6J, 8 wk of age, n = 146) were inoculated with a neurotropic strain of mouse hepatitis virus (A59 strain) and followed for 4 wk. Inoculation with...

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Identifiers

PMID: 25007876
DOI: 10.1152/ajprenal.00151.2014
PMCID: PMC4154110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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