Article
Clemastine effects in rat models of a myelination disorder.
Pediatric research - 1 Jun 2018
Turski Christopher A, Turski Gabrielle N, Chen Bingming, Wang Hauhui, Heidari Moones, Li Lingjun, Noguchi Kevin K, Westmark Cara, Duncan Ian, Ikonomidou Chrysanthy
Abstract excerpt
BackgroundPelizaeus Merzbacher disease (PMD) is a dysmyelinating disorder of the central nervous system caused by impaired differentiation of oligodendrocytes. This study was prompted by findings that antimuscarinic compounds enhance oligodendrocyte differentiation and remyelination in vitro. One of these compounds, clemastine fumarate, is licensed for treatment of allergic conditions. We tested whether...
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