Article
[Analysis of the effect of N5, N10-methylenetetrahydrofolate reductase gene C(677)-->T polymorphism on the ischemic stroke development in persons with various risk factors].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) - 1 Jan 2014
Harbuzova V Iu, Polonikov O V, Stroĭ D O, Matlaĭ O I, Ataman Iu O, Sukharieva V A, Ataman O V
Abstract excerpt
The results ofMTHFR gene C(677)-->T (rs1801133) polymorphism determined in 170 patients with ischemic atherothrombotic stroke (IATS) and 124 healthy subjects (control group) are presented in the paper. It has been shown that in patients with IATS, the frequencies of main homozygotes (CC), heterozygotes (CT) and minor homozygotes (TT) are 52.4, 35.9, 11.8% (in control--46.0, 48.4, 5.6%, P = 0.044 by chi2-test). TT...
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