Article
Decreased phenotypic susceptibility to etravirine in patients with predicted genotypic sensitivity.
PloS one - 1 Jan 2014
Agneskog Eva, Nowak Piotr, Maijgren Steffensson Catharina, Casadellà Maria, Noguera-Julian Marc, Paredes Roger, Källander Clas F R, Sönnerborg Anders
Abstract excerpt
BACKGROUND: A sensitive, phenotypic reverse transcriptase (RT)-based drug susceptibility assay for the detection of etravirine (ETR) resistance in patient isolates was developed and compared with the results from direct sequencing and ultra-deep pyrosequencing (UDPS). METHODS: Samples were obtained from 15 patients with antiretroviral therapy (ART) failure and from five non-nucleoside reverse transcriptase...
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