Article
Calreticulin mutations in Chinese with primary myelofibrosis.
Haematologica - 1 Nov 2014
Li Bing, Xu Junqing, Wang Jingya, Gale Robert Peter, Xu Zefeng, Cui Yajuan, Yang Lin, Xing Ruixian, Ai Xiaofei, Qin Tiejun, Zhang Yue, Zhang Peihong, Xiao Zhijian
Abstract excerpt
We tested 357 Chinese with primary myelofibrosis for mutations in CALR, JAK2 and MPL. CALR mutations were detected in 76 subjects (21%). There were 24 (32%) type-1 (L367fs*46) and 49 (64%) type-2 (K385fs*47) mutations. Seventy-two of 168 subjects (43%) without a JAK2 or MPL mutation had a CALR mutation. Subjects with a type-2 CALR mutation had lower hemoglobin concentrations (P=0.001), lower WBC counts (P<0.001),...
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