Article
Let-7c governs the acquisition of chemo- or radioresistance and epithelial-to-mesenchymal transition phenotypes in docetaxel-resistant lung adenocarcinoma.
Molecular cancer research : MCR - 1 Jul 2013
Cui Shi-Yun, Huang Jia-Yuan, Chen Yi-Tian, Song Hai-Zhu, Feng Bing, Huang Gui-Chun, Wang Rui, Chen Long-Bang, De Wei
Abstract excerpt
MicroRNA (miRNA) expression and functions have been reported to contribute to phenotypic features of tumor cells. Although targets and functional roles for many miRNAs have been described in lung adenocarcinoma (LAD), their pathophysiologic roles in phenotypes of chemoresistant LAD cells are still largely unclear. Previously, docetaxel (DTX)-resistant LAD cell lines (SPC-A1/DTX and H1299/DTX) were established by...
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