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Article

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.

PLoS genetics - 1 Jul 2017

El Shahawy Maha, Reibring Claes-Göran, Neben Cynthia L, Hallberg Kristina, Marangoni Pauline, Harfe Brian D, Klein Ophir D, Linde Anders, Gritli-Linde Amel

Abstract excerpt

The interaction between signaling pathways is a central question in the study of organogenesis. Using the developing murine tongue as a model, we uncovered unknown relationships between Sonic hedgehog (SHH) and retinoic acid (RA) signaling. Genetic loss of SHH signaling leads to enhanced RA activity subsequent to loss of SHH-dependent expression of Cyp26a1 and Cyp26c1. This causes a cell identity switch,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28715412
DOI: 10.1371/journal.pgen.1006914
PMCID: PMC5536368

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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