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Article

Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling

28 Nov 2016

Abstract excerpt

For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions. To investigate a role for Hedgehog/GLI signaling in adult taste organs we used a panel of conditional mouse models to manipulate GLI activity within epithelial cells of the fungiform and circumvallate papillae. Hedgehog signaling suppression rapidly led to...

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PMID: 27893742
DOI: 10.1371/journal.pgen.1006442

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