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Article

Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy

1 Jul 2014

Abstract excerpt

miRNAs are important regulators of biological processes in many tissues, including the differentiation and function of brown and white adipocytes. The endoribonuclease dicer is a major component of the miRNA-processing pathway, and in adipose tissue, levels of dicer have been shown to decrease with age, increase with caloric restriction, and influence stress resistance. Here, we demonstrated that mice with a...

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PMID: 24983316
DOI: 10.1172/jci73468

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